The spectacle deeply frightened many Russians, with some elderly women declaring that the world was coming to an end. Many of the injured were cut by flying glass as they flocked to windows to see what the reason was for such an intense flash of light.
Amateur video showed an object speeding across the sky about 9:20 a.m. local time, just after sunrise, leaving a thick white contrail and an intense flash.
"There was panic. People had no idea what was happening," said Sergey Hametov, a resident of Chelyabinsk, a city of 1 million about 1,500 kilometers (930 miles) east of Moscow.
"We saw a big burst of light, then went outside to see what it was and we heard a really loud, thundering sound," he told The Associated Press by telephone.
The meteor released several kilotons of energy above the region, the science academy said. It was probably about 2 meters (6.5 feet) across, about the size of an SUV, said Richard Binzel, a professor of Planetary Science at MIT.
The shock wave blew in an estimated 100,000 square meters (more than 1 million square feet) of glass, according to city officials, who said 3,000 buildings in the city were damaged. At one zinc factory, part of the roof collapsed.
The meteor hit less than a day before Asteroid 2012 DA14 is to make the closest recorded pass of an asteroid to the Earth - about 17,150 miles (28,000 kilometers). But the European Space Agency in a tweet said its experts had determined there was no connection - just cosmic coincidence.
The Interior Ministry said 985 people sought medical care after the shock wave and 44 of them were hospitalized. Most of the injuries were caused by flying glass, officials said.
There was no immediate word on any deaths or anyone struck by space fragments.
Meteors typically cause sizable sonic booms when they enter the atmosphere because they are traveling so much faster than the speed of sound. Injuries on the scale reported Friday, however, are extraordinarily rare.
"I went to see what that flash in the sky was about," recalled resident Marat Lobkovsky. "And then the window glass shattered, bouncing back on me. My beard was cut open, but not deep. They patched me up. It's OK now."
Another resident, Valya Kazakov, said some elderly women in his neighborhood started crying out that the world was ending.
Russian-language hashtags for the meteorite quickly shot up into Twitter's top trends.
Lessons had just started at Chelyabinsk schools when the meteor exploded, and officials said 204 schoolchildren were among those injured. Amateur video footage showed a teacher speaking to her class as a powerful shock wave hit the room.
Yekaterina Melikhova, a high school student whose nose was bloody and whose upper lip was covered with a bandage, said she was in her geography class when a bright light flashed outside.
"After the flash, nothing happened for about three minutes. Then we rushed outdoors. I was not alone, I was there with Katya. The door was made of glass, a shock wave made it hit us," she said.
Russian television ran footage of athletes at a city sports arena who were showered by shards of glass from huge windows. Some of them were still bleeding.
Other videos showed a long shard of glass slamming into the floor close to a factory worker and massive doors blown away by the shock wave.
The vast implosion of glass windows exposed many residents to the bitter cold as temperatures in the city were expected to plummet to minus 20 Celsius (minus 4 Fahrenheit) overnight.
The regional governor immediately urged any worker who can pane windows to rush to the area to help out.
Some meteorite fragments fell in a reservoir outside the town of Chebarkul, the regional Interior Ministry office said. The crash left an eight-meter (26-foot) -wide crater in the ice.
Meteroids are small pieces of space debris - usually parts of comets or asteroids - that are on a collision course with the Earth. They become meteors when they enter the Earth's atmosphere. Most meteors burn up in the atmosphere, but if they survive the frictional heating and strike the surface of the Earth they are called meteorites.
The site of Friday's spectacular show is about 5,000 kilometers (3,000 miles) west of Tunguska, which in 1908 was the site of the largest recorded explosion of a space object plunging to Earth. That blast, attributed to a comet or asteroid fragment, is generally estimated to have been about 10 megatons; it leveled some 80 million trees.
Scientists believe that a far larger meteorite strike on what today is Mexico's Yucatan Peninsula may have been responsible for the extinction of the dinosaurs about 66 million years ago. According to that theory, the impact would have thrown up vast amounts of dust that blanketed the sky for decades and altered the climate on Earth.
The meteor could have produced much more serious problems. Chelyabinsk is an industrial town long held to be one of the world's most polluted areas, and the area around it hosts nuclear and chemical weapons disposal facilities.
Vladimir Chuprov of Greenpeace Russia said the Russian government has underestimated potential risks of the region. He noted that the meteor struck only 100 kilometers (60 miles) from the Mayak nuclear storage and disposal facility, which holds dozens of tons of weapons-grade plutonium.
A chemical weapons disposal facility at Shchuchye also contains some 6,000 tons (5,460 metric tons) of nerve agents, including sarin and VX, about 14 percent of the chemical weapons that Russia is committed to destroy.
The panic and confusion that followed Friday's meteorite crash quickly gave way to typical Russian black humor and entrepreneurial instincts.
Several people smashed in the windows of their houses in the hopes of receiving compensation, the RIA Novosti news agency reported.
Others quickly took to the Internet and put what they said were meteorite fragments up for sale.
One of the most popular jokes was that the meteorite was supposed to fall on Dec. 21 last year - when many believed the Mayan calendar predicted the end of the world - but was delivered late by Russia's notoriously inefficient postal service.
The dramatic event prompted an array of reactions from prominent Russians.
Prime Minister Dmitry Medvedev, speaking at an economic forum in the Siberian city of Krasnoyarsk, said the meteor could be a symbol for the forum, showing that "not only the economy is vulnerable, but the whole planet."
Vladimir Zhirinovsky, a nationalist leader noted for his vehement statements, blamed the Americans.
"It's not meteors falling. It's the test of a new weapon by the Americans," the RIA Novosti news agency quoted him as saying.
Deputy Prime Minister Dmitry Rogozin said the incident showed the need for leading world powers to develop a system to intercept objects falling from space.
"At the moment, neither we nor the Americans have such technologies" to shoot down meteors or asteroids, he said, according to the Interfax news agency.
Jim Green, NASA's director of planetary science, called the back-to-back celestial events an amazing display.
"This is indeed very rare and it is historic," he said on NASA TV. "These fireballs happen about once a day or so, but we just don't see them because many of them fall over the ocean or in remote areas."